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It is vital to understand the contribution of resident intestinal bacteria to the environmental flow of antimicrobial resistance genes. We will isolate resistant commensal bacteria from diverse sources, assess the co-carriage of heavy metal resistance genes on mobile genetic elements, compare identical resistance genes between non-harmful and pathogenic bacteria, and investigate the impact selective pressure has on gene evolution and transfer.
Investigation of how pathogens responsible for key welfare and production-limiting diseases of Scottish livestock are transmitted to their host animal, determining the key pathogens that are important for infection and disease, and how they interact with the host immune system.
This project is investigating the spread of tick-transmitted zoonotic pathogens to generate knowledge directly applicable to the management of green spaces and wildlife. In particular, we are assessing potential practical solutions to the increase in spread of vectors (ticks) and associated diseases.
Infectious diseases, particularly when caused by antibiotic-resistant pathogens, are major problems in farmed animals. New treatments are urgently needed to reduce infections. We aim to address this by harnessing the animal intestinal microbiome to boost their defence. We will screen our diverse gut bacterial culture collections to identify health-associated microbes with potent activity against pathogens, including antibiotic resistant strains
The climate emergency presents a double challenge for public bodies as they reduce their greenhouse gas emissions and learn to adapt to the already changing climate. The Scottish government is committed to delivering a Just Transition to Net Zero by 2045 meaning that public entities must come up with innovative ways to meet these targets. The Loch Lomond and the Trossachs National Park Authority (LLTNPA) covers a largely rural area in the west of Scotland and want to address the ‘wicked issues' of rural car dependency and carbon-intensive travel to Loch Lomond and Trossachs National Park
Ashleigh's research interests are in microbial pathogenicity, particularly in the regulation and expression of virulence factors. Enterohaemorrhagic E. coli O157:H7 are important food-borne pathogens which colonise ruminants as commensals. Disease outbreaks are commonly associated with the consumption of contaminated meat or via direct contact, however a significant number have been attributed to the consumption of fresh produce (such as spinach, lettuce and radishes). During Ashleigh's PhD, she was interested in how type III secretion system effectors, particularly non-LEE encoded effectors
This project develops a range of advanced laboratory-based systems to investigate how production- and welfare-limiting diseases of Scottish livestock establish infections in their hosts. Our work is underpining the development of novel vaccines and diagnostic tests by identifying the animal's response to disease and it’s initiation of protection as well as providing new methods for pathogen isolation and identification.
The project is mitigating threats posed to key crops by new, emerging and endemic pests and pathogens, to protect Scotland’s industries and delivering integrated and sustainable crop protection strategies for Scottish growers.
We all know that eating fish is good for health. Fish represents a great source of lean protein, unique omega- 3 fatty acids and bioavailable micronutrients which are often lacking in plant-based diets. In addition, fish offers an alternative animal-based product with a lower environmental footprint. One of the main health benefits of eating fish is that it reduces the risk of cardiovascular disease and stroke. Many countries have therefore drawn up dietary recommendations for seafood consumption as part of their national dietary guidelines; similar to the UK’s five portions of fruit and