Virus infection in seed potato crops has surged across Europe over the last five years, threatening Scotland’s global reputation for producing high-quality seed. A multi-pronged approach was developed: mapping changing aphid and virus populations and their traits, using AI to create national early warning systems for forecasting risk, and field-testing integrated pest management (IPM) strategies—combining monitoring with companion crops and pesticide alternatives. This real-world approach guides best practice, helping growers time interventions and improve crop protection.